University of Florida

Qui-Xing Jiang, Ph.D.

Current Directions:

Investigate the mechanism behind the lipid-dependent effects on voltage-gated potassium (Kv) channels and the connection to lipid metabolic defects in human. We discovered strong inhibitory effects of nonphospholipids, such as cholesterol and glycosphingolipids, on Kv channels, and are studying their roles in the sever neurological diseases caused by lipid metabolic defects. ary to infection and immunity our lab has an active interest in improving oocyte cryopreservation and the developmental environment of the early embryo.

Understand the molecular basis of a granin family protein in every step of the regulated secretory pathway, and the importance of these proteins in the impaired secretion in human diseases, such as type 2 diabetes, as well as their importance to the metastasis and survival of human neuroendocrine cancer cells.

Structural and functional studies of membrane proteins and intracellular RNA-binding complexes and their relation to human diseases including cancers and neuroendocrine defects.

Representative Publications:
Hui Zheng, Sungsoo Lee, Marc C. Llaguno, and Qiu-Xing Jiang. bSUM: a bead-supported unilamellar membrane system enabling unidirectional insertion of membrane proteins into giant vesicles. (2016) Journal of General Physiology. 147(1):77-93. PMID: 26712851

Hui Xu, Xiaojing He, Hui Zheng, Zhiheng Yu, Brian Borkowski, Xuewu Zhang, Zhijian J. Chen and Qiu-Xing Jiang. Structural basis for the prion-like MAVS filaments in antiviral innate immunity. (2014) eLife. 3:e01489.

Marc Llaguno, Hui Xu, Liang Shi, Nian Huang, Hong Zhang, Qinghua Liu, and Qiu-Xing Jiang. Chemically functionalized nanometer-thick carbon films for single molecule imaging. (2014) J. Struct. Biology. Jan 21. pii: S1047-8477(14)00007-0. doi: 10.1016/j.jsb.2014.01.006.

Hui Zheng, Weiran Liu, Lingyan Anderson, and Qiu-Xing Jiang. Lipid-dependent gating of a voltage-gated potassium channel. (2011). Nature Communications 2:250 doi: 10.1038/ncomms1254.


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Qui-Xing Jiang, Ph.D.
Associate Professor
Department of Microbiology & Cell Science
Ph.D., Yale University
Postdoc: Yale University; Rockefeller University