University of Florida

Stephanie Wohlgemuth, Ph.D.

The primary goal of my research is to understand the role of autophagy in age-related muscle loss, and to test interventions to preserve muscle mass and health with age, such as calorie restriction and exercise. Autophagy is one of the degradative mechanisms that cells possess to clear intracellular “waste” and to prevent the accumulation of damaged and potentially toxic intracellular materials. When autophagy fails or becomes deregulated, however, cells might be seriously impacted by accumulating “waste” and die. I am particularly interested in the interrelationship of aging and autophagy in skeletal muscle.

My lab will use rodent and livestock models as well as cultured cell models to investigate the effects of aging and dietary and exercise regimens on skeletal muscle cells with special emphasis on autophagy and other degradative mechanisms. We will employ physiological, biochemical, and molecular techniques to answer questions related to the effects of different calorie restriction regimes, supplements, and exercise on muscle cell health, including mitochondrial function and cellular maintenance through autophagy and other degradative mechanisms; the balance that ensures efficient cellular maintenance without excessive degradation and atrophy; and the balance between protein synthesis and degradation.

Representative Publications:
Selberg KT, Lowe AC, Staples CR, Luchini DN, Badinga L. Production and metabolic responses of periparturient Holstein cows to dietary conjugated linoleic acid and trans-octadecenoic acids.  J Dairy Sci 2004; 87:158-168.

Selberg KT, Staples CR, Luchini ND, Badinga L.  Dietary trans octadecenoic acids upregulate the liver gene encoding peroxisome proliferator-activated receptor-a in transition dairy cows.  J Dairy Res 2005; 72:107-114.

Balaguer SA, Pershing RA, Rodriguez-Sallaberry C, Thatcher WW, Badinga L.  Effects of bovine somatotropin on uterine genes related to the prostaglandin cascade in lactating dairy cows.  J Dairy Sci 2005; 88:543-552.

Caldari-Torres C, Rodriguez-Sallaberry C, Johnson ES, Badinga L.  Eicosapentaenoic acid and peroxisome proliferator-activated receptor delta regulate prostaglandin F2a production through distinct signaling mechanisms in bovine endometrial cells.  Biol Reprod 2005; (submitted).

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wohlgemuth

Stephanie Wohlgemuth, Ph.D.
Assistant Professor
Department of Animal Sciences
Ph.D., Institute for Zoophysiology, HHU Düsseldorf, Germany
Postdoc., Institute for Genetics, HHU Düsseldorf, Germany

Department of Animal Sciences: Faculty Page